Gabapentin pharmacotherapy for antipsychotic-induced akathisia: single-patient experiment and case report

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Acute antipsychotic-induced akathisia revisited.

Akathisia remains one of the most prevalent and distressful antipsychotic-induced adverse events. Effective and well-tolerated treatment is a major unmet need in akathisia that merits a search for new remedies. Accumulating evidence indicates that agents with marked serotonin-2A receptor antagonism may represent a new class of potential anti-akathisia treatment.

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Akathisia is a common side-effect of the neuroleptic drugs and occurs in about 5% to 75% cases treated with these compounds (Barnes et al., 1985; Van Putten et at., 1984). In addition, akathisia like syndromes are produced with conditions such as uremia, idiopathic restless legs syndrome, congestive heart failure, idiopathic parkinsonism, and with drugs such as reserpine, .trycyclic antidepress...

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Revisiting Antipsychotic-induced Akathisia: Current Issues and Prospective Challenges

BACKGROUND Akathisia continues to be a significant challenge in current neurological and psychiatric practice. Prompt and accurate detection is often difficult and there is a lack of consensus concerning the neurobiological basis of akathisia. No definitive treatment has been established for akathisia despite numerous preclinical and clinical studies.] Method: We reviewed antipsychotic-induced ...

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Drug-induced Akathisia - a Preliminary Report

25 in-patients, 17 males and 8 females, were administered Barnes' Scale for drug-induced Akathisia. Akathisia was found in 7 of them, 5 males and 2 females. One had pseudoakathisia and in the other, akathisia was questionable. The inter-rater reliability, assessed by weighted Cohen's kappa, was found to be high.

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Background: Akathisia is a common adverse effect of antipsychotic drugs and is characterized by subjective feelings of restlessness. First-line treatment usually consists of propranolol, a beta adrenergic antagonist. However, propranolol does not seem to be efficacious in up to 70% of patients. This study was aimed to evaluate the effect of vitamin B6 versus propranolol on antipsychotic-induced...

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ژورنال

عنوان ژورنال: Therapeutic Advances in Psychopharmacology

سال: 2014

ISSN: 2045-1253,2045-1261

DOI: 10.1177/2045125314525433